Chemistry 5853                     PRINCIPLES OF BIOCHEMISTRY II      Spring 2008

 

TuTh  12:00 - 1:20 PM     Stephenson Research and Technology Center, Classroom on First Floor

Professor:        Bruce A. Roe

Office:             2107 Stephenson Research and Technology Center

Office Hours:  1:30 - 2:30  M-F, other times by appointment

Web Site:        www.genome.ou.edu

E-mail:             broe@ou.edu

 

Text:    Genes IX by Benjamin Lewin,

            Published by Prentice Hall, 2003 : ISBN: 0-13-143981-2

 

Chemistry 5853-001 is an Advanced Topics in Biochemistry course with an emphasis on Genomics at the graduate level.  The prerequisite for this course is the successful completion of Chemistry 5853 (Principles of Biochemistry I) or being enrolled in Chemistry 5853 or equivalent.

 

The major goal of this course is to give the student in depth knowledge of genomics from the nucleic acid perspective (i.e., nucleotide, DNA, RNA) structure and function, as well as the mechanisms of replication, transcription, translation, and gene expression in procaryote, eucaryote, bacteriophage and animal viruses. With the complete sequence of the human genome, as well as that of several other eukaryote and prokaryote organisms, this course also will focus on understanding this new wealth of genomic information and how it can be applied to research in biochemistry molecular biology and genomics.  The text, Genes IX by Benjamin Lewin provides an excellent background for these topics.  Additional material covering these topics can be found in Zubay's Biochemistry in parts IV and V, as well as in Genes & Genomes, by Maxine Singer and Paul Berg. Additional readings will be assigned from the literature and a section of the course will include aspects of computational biology and bioinformatics.

 

The lecture material will follow the order presented in Genes IX.   Students are encouraged to read and outline the text prior to attending the class meeting.  Each part (group of chapters) ends with a list of additional selected readings which students may find useful.  Students are responsible for understanding the content of journal articles distributed in class and other handed-outs.

 

Grading for this course will entail two (2) hourly exams (100 points each) and a comprehensive final exam (200 points).  There also may be one or more homework assignments which will be graded and included in the final grading assessment.

 

IT IS STRONGLY RECOMMENDED THAT STUDENTS

1.   Read and outline the text material prior to the class meeting.

2.   Answer the questions/study exercises/problems at the end of each chapter before the quizzes and exams.

3.   Take lecture notes and coordinate their notes with the text, questions/study exercises/problems at the end of each chapter.

4.   Contact Dr. Roe prior to missing a lecture and/or quiz, if possible.

 

UNIVERSITY POLICY, STIPULATIONS, and DISCLAIMER

1.   Any student in this course who has a disability that may prevent them from fully demonstrating their abilities should contact Dr. Roe as soon as possible to discuss accommodations needed to ensure full participation and facilitate their educational opportunity

2.   Each student should acquaint themselves with the University of Oklahoma code, policies, and procedures involving academic misconduct, grievances, sexual and ethnic harassment, and discrimination.

3.   Dr. Roe reserves the right to change by addition and/or subtraction any and/or all materials contained in this syllabus.  This includes, but is not limited to, course content, assignments, due dates, and portions(s) of the grade assigned to individual items within this course.