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21. Iyer, K., Crabtree, J., Clifton, S., Chissoe, S., Mardis, E., and Roe, B.A., "Supercoiled DNA isolation using diatomaceous earth", in press.

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26. Chissoe, S.L., Wang, Y.F., Clifton, S.W., Ma, N., Sun, H.J., Lobsinger, J.S., Kenton, S.M., White, J.D., and Roe, B.A., "Strategies for rapid and accurate DNA sequencing", Methods: Companion Methods Enzymol. 3, 55-65 (1991).

27. Federal Bureau of Investigation, RFLP Manual, U.S. Government 1993.

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29. Johnston-Dow, L., Mardis, E., Heiner, C., and Roe, B.A., "Optimized methods for fluorescent and radiolabeled DNA sequencing", BioTechniques 5, 754-765 (1987).

29. T. Favello and R.K. Wilson, personal communication

30. Protocol included with the ABI PRISM Sequenase[TM] Terminator Single-Stranded DNA Sequencing Kit, part number 401458.

31. Protocol included with the ABI PRISM Sequenase[TM] Terminator Double-Stranded DNA Sequencing Kit, part number 401461.

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35. R.K. Wilson, personal communication

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38. Beckman Oligo 1000 Synthesizer manual

39. ABI 392 Synthesizer manual

40. Beaucage, S.L. and Caruthers, M., "Deoxynucleoside phosphoramidites: A new class of key intermediates for deoxypolynucleotide synthesis", Tetrahedron Letters 22, 1859-1862 (1981).

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43. Eadie, J.S. and Davidson, D.S., "Guanine modification during chemical DNA synthesis", Nucl. Acids Res. 15, 8333-8349 (1987).

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45. Smith, L.M., Kaiser, R.J., Sanders, J.Z., and Hood, L.E., "The synthesis and use of fluorescent oligonucleotides in DNA sequence analysis", Meth. Enzymol. 155, 260-301 (1987).

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Bruce A. Roe, Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma 73019